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Title: Designed glucopeptides mimetics of myelin protein epitopes as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis.
identifier: 1966851
description:
epitope description:VVHLYRNGKDQDGDQAPEYRG + GLUC(N7)
antigen name:Myelin-oligodendrocyte glycoprotein (UniProt:Q16653)
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 23167575
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1025349
landingPage: http://www.iedb.org/assay/1966851
type:
Literature
publicationVenue:
J Med Chem
dates:
2012
study type: b cell assays
subject species: Homo sapiens
fullName:
Shashank Pandey
Maria C Alcaro
Mario Scrima
Elisa Peroni
Ilaria Paolini
Sara Di Marino
Francesca Barbetti
Alfonso Carotenuto
Ettore Novellino
Anna Maria Papini
Anna Maria D'Ursi
Paolo Rovero
method:
antigen inhibition (~ IC50)
name:
Designed glucopeptides mimetics of myelin protein epitopes as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis.
description:
For a single MS patient serum, reactivity in inhibition ELISA were the soluble epitope inhibited binding to a solid-phase artificial analog (TPRVERNGHSVFLAPYGWMVK + GLUC(N7)) was tested.

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