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Title: The core cysteines, (C909) of islet antigen-2 and (C945) of islet antigen-2beta, are crucial to autoantibody binding in type 1 diabetes.
identifier: 1967175
description:
epitope description:W799, E836
antigen name:Receptor-type tyrosine-protein phosphatase-like N
host organism:Mus musculus BALB/c
antibody name:MAb-A5
aggregation:
instance of dataset
availability:
available
primaryPublications: 22966073
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1025347
landingPage: http://www.iedb.org/assay/1967175
type:
Literature
publicationVenue:
Diabetes
dates:
2013
study type: b cell assays
subject species: Homo sapiens
fullName:
Karen T Elvers
Ivey Geoghegan
Debbie K Shoemark
Vito Lampasona
Polly J Bingley
Alistair J K Williams
method:
radio immuno assay (RIA)
name:
The core cysteines, (C909) of islet antigen-2 and (C945) of islet antigen-2beta, are crucial to autoantibody binding in type 1 diabetes.
description:
The epitope was derived from the author provided GenBank identifier L18983 (GI:499630).
Mutations E836K abolished binding of the Mab to IA-2 and mutation W799A caused a 78% reduction in binding. These residues were therefore considered to play a critical role in binding.

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