Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1967614 |
| description: |
epitope description:alpha-D-GlcN-(1->2)-alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep4P-(1->3)-L-alpha-D-Hep4P-(1->5)-[alpha-D-Kdo-(2->4)]-alpha-D-Kdo-(2->6)-beta-D-GlcN4P-(1->6)-alpha-D-Glc1P
antigen name:lipopolysaccharide
host organism:Mus musculus NZB
antibody name:WN1 225-5
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
23184990 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1025383 |
| landingPage: |
http://www.iedb.org/assay/1967614 |
| type: |
Literature
|
| publicationVenue: |
Proc Natl Acad Sci U S A
|
| dates: |
2012
|
| study type: | b cell assays |
| subject species: | Escherichia coli F576 |
| fullName: |
Kathryn Gomery
Sven Mü
ller-Loennies
Cory L Brooks
Lore Brade
Paul Kosma
Franco Di Padova
Helmut Brade
Stephen V Evans
|
| method: |
x-ray crystallography
|
| name: |
Antibody WN1 222-5 mimics Toll-like receptor 4 binding in the recognition of LPS.
|
| description: |
The crystal structure of WN1 222-5 Fab in complex with the epitope, dodecasaccharide-P4, was determined by molecular replacement. Dodecasaccharide-P4 is the major oligosaccharide of the E. coli R2 core type. Seven sugar residues contact the Fab, including the Hep and Kdo residues of the conserved inner core and the adjacent Glc and branched Gal of the outer core.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
