Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoprotein.

Title:

Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoprotein.

Dataset

identifier:	1968743
description:	epitope description:NIQLINTNGSWHINST antigen name:Genome polyprotein host organism:Homo sapiens antibody name:HC33.10
aggregation:	instance of dataset
availability:	available
primaryPublications:	23097455

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1025364
landingPage:	http://www.iedb.org/assay/1968743

Publication

type:	Literature
publicationVenue:	J Virol
dates:	2013

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus (isolate H77)

Person

fullName:	Zhenyong Keck Wenyan Wang Yong Wang Patrick Lau Thomas H R Carlsen Jannick Prentoe Jinming Xia Arvind H Patel Jens Bukh Steven K H Foung

Data Type

method:	surface plasmon resonance (SPR)

Study

name:	Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoprotein.
description:	Affinity values for each epitope specific scFv were calculated by SPR.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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