Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1968561 |
| description: |
epitope description:NIQLINTNGSWHINST
antigen name:Genome polyprotein
host organism:Homo sapiens
antibody name:HC33.4, HC33.29, HC33.2.1, HC33.2.4, HC33.2.8, HC33.3.1, HC33.3.4, HC33.3.8, HC33.6.4, HC33.6.8
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
23097455 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1025364 |
| landingPage: |
http://www.iedb.org/assay/1968561 |
| type: |
Literature
|
| publicationVenue: |
J Virol
|
| dates: |
2013
|
| study type: | b cell assays |
| subject species: | Hepatitis C virus (isolate H77) |
| fullName: |
Zhenyong Keck
Wenyan Wang
Yong Wang
Patrick Lau
Thomas H R Carlsen
Jannick Prentoe
Jinming Xia
Arvind H Patel
Jens Bukh
Steven K H Foung
|
| method: |
biological activity
|
| name: |
Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoprotein.
|
| description: |
The epitope-specific mAbs HC33.4 and HC33.29 were shown to weakly neutralize chimeric 2a JFH1 HCVcc bearing C, E1, E2, p7, and NS2 from different genotypes. The epitope-specific affinity matured mAbs (HC33.2.1, HC33.2.4, HC33.2.8, HC33.3.1, HC33.3.4, HC33.3.8, HC33.6.4, HC33.6.8) were shown to block cell infection by 2a JFH1 HCVcc by >80%.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
