Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoprotein.

Title:

Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoprotein.

Dataset

identifier:	1968565
description:	epitope description:NIQLINTNGSWHINST antigen name:Genome polyprotein host organism:Homo sapiens antibody name:HC33.8, HC33.29
aggregation:	instance of dataset
availability:	available
primaryPublications:	23097455

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1025364
landingPage:	http://www.iedb.org/assay/1968565

Publication

type:	Literature
publicationVenue:	J Virol
dates:	2013

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus (isolate H77)

Person

fullName:	Zhenyong Keck Wenyan Wang Yong Wang Patrick Lau Thomas H R Carlsen Jannick Prentoe Jinming Xia Arvind H Patel Jens Bukh Steven K H Foung

Data Type

method:	biological activity

Study

name:	Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoprotein.
description:	The epitope-specific mAbs were shown to neutralize chimeric 2a JFH1 HCVcc bearing C, E1, E2, p7, and NS2 from different genotypes. Titration studies to calculate the 50% inhibitory concentration (IC50) against HCVcc in genotypes 1 to 6 were also performed for HC33.4 only.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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