Structure and properties of a complex of alpha-synuclein and a single-domain camelid antibody. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Structure and properties of a complex of alpha-synuclein and a single-domain camelid antibody.

Dataset

identifier:	1970929
description:	epitope description:YEPEA antigen name:Alpha-synuclein host organism:Camelus dromedarius antibody name:NbSyn2
aggregation:	instance of dataset
availability:	available
primaryPublications:	20620148

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1025021
landingPage:	http://www.iedb.org/assay/1970929

Publication

type:	Literature
publicationVenue:	J Mol Biol
dates:	2010

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Erwin J De Genst Tim Guilliams Joke Wellens Elizabeth M O'Day Christopher A Waudby Sarah Meehan Mireille Dumoulin Shang-Te Danny Hsu Nunilo Cremades Koen H G Verschueren Els Pardon Lode Wyns Jan Steyaert John Christodoulou Christopher M Dobson

Data Type

method:	nuclear magnetic resonance (NMR)

Study

name:	Structure and properties of a complex of alpha-synuclein and a single-domain camelid antibody.
description:	NMR mapping of epitope-specific camelid antibody NbSyn2 bound to alpha-synuclein showed that the primary epitope was located within residues 130-140. NbSyn2 bound to alpha-synuclein monomers and fibrils.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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