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Title: Immunogenicity, efficacy, safety, and mechanism of action of epitope vaccine (Lu AF20513) for Alzheimer's disease: prelude to a clinical trial.
identifier: 1974130
description:
epitope description:DAEFRHDSGYEV
antigen name:Amyloid beta A4 protein
host organism:Mus musculus APPsw
aggregation:
instance of dataset
availability:
available
primaryPublications: 23486963
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1025622
landingPage: http://www.iedb.org/assay/1974130
type:
Literature
publicationVenue:
J Neurosci
dates:
2013
study type: b cell assays
subject species: Homo sapiens
fullName:
Hayk Davtyan
Anahit Ghochikyan
Irina Petrushina
Armine Hovakimyan
Arpine Davtyan
Anna Poghosyan
Annette M Marleau
Nina Movsesyan
Anatoly Kiyatkin
Suhail Rasool
Anna Kirstine Larsen
Peter Juul Madsen
Karen Malene Wegener
Dorte Kornerup Ditlevsen
David H Cribbs
Lars Ostergaard Pedersen
Michael G Agadjanyan
method:
in vivo assay
name:
Immunogenicity, efficacy, safety, and mechanism of action of epitope vaccine (Lu AF20513) for Alzheimer's disease: prelude to a clinical trial.
description:
Vaccination with the epitope vaccine Lu AF20513 significantly reduces AD-like pathology in aged Tg2576 mice. A decrease in hemibrain plaque burden in mice immunized with Lu AF20513 and reduced glial activation without increasing cerebral amyloid angiopathy and microhemorrhages was seen.

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