Impact of antibodies against amyloidogenic transthyretin (ATTR) on phenotypes of patients with familial amyloidotic polyneuropathy (FAP) ATTR Valine30Methionine.

Title:

Impact of antibodies against amyloidogenic transthyretin (ATTR) on phenotypes of patients with familial amyloidotic polyneuropathy (FAP) ATTR Valine30Methionine.

Dataset

identifier:	1975946
description:	epitope description:PAINVAMHVFRK antigen name:Transthyretin host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	23462670

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1025715
landingPage:	http://www.iedb.org/assay/1975946

Publication

type:	Literature
publicationVenue:	Clin Chim Acta
dates:	2013

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Konen Obayashi Masayoshi Tasaki Hirofumi Jono Mitsuharu Ueda Satoru Shinriki Yohei Misumi Taro Yamashita Toshinori Oshima Teruya Nakamura Shinji Ikemizu Intissar Anan Ole Suhr Yukio Ando

Data Type

method:	ELISA

Study

name:	Impact of antibodies against amyloidogenic transthyretin (ATTR) on phenotypes of patients with familial amyloidotic polyneuropathy (FAP) ATTR Valine30Methionine.
description:	The epitope sequence is from the cited reference: Tawara et al (1983) Biochem Biophys Res Commun 116: 880-888 [PMID: 6651852]. There was a positive correlation between the level of antibody to the epitope and the age at onset of FAP ATTR V30M in these patients.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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