Immunological Data Discovery Index
Immunological Data Discovery Index
| Title: | Crystal structure of alpha5beta1 integrin ectodomain: atomic details of the fibronectin receptor. |
| identifier: | 1974358 |
| description: |
epitope description:N97, R98, S99, K100, G101, T102, A103, E104, K105, E139, D140, N171, R174, R175, I176, T177, S178, S419, I420
antigen name:Integrin beta-1
host organism:Mus musculus BALB/c
antibody name:SG/19
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| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
22451694 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1024886 |
| landingPage: |
http://www.iedb.org/assay/1974358 |
| type: |
Literature
|
| publicationVenue: |
J Cell Biol
|
| dates: |
2012
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Masamichi Nagae
Suyong Re
Emiko Mihara
Terukazu Nogi
Yuji Sugita
Junichi Takagi
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| method: |
x-ray crystallography
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| name: |
Crystal structure of alpha5beta1 integrin ectodomain: atomic details of the fibronectin receptor.
|
| description: |
The epitope is located on integrin beta-1. The epitope residues were calculated from [PDB: 3VI3] as the antigen residues at 4 Å
atomic distance from the antibody. The epitope calculated from [PDB: 3VI4] contained one additional residue, K87.
The epitope of SG/19 Fab on the headpiece fragment of alpha5ß1 integrin was determined from the crystal structure of the complex. The complex was crystallized in the presence of physiological concentrations of Mg2+ and Ca2+. Two alpha5beta1–Fab complexes contained in one crystallographic asymmetric unit were essentially identical. Therefore, only one complex discussed in the paper (chains A, B, E, and F) is curated here.
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| name: |
iedb
|
| homePage: |
http://www.iedb.org |