Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1974506 |
| description: |
epitope description:P122, N124, N125, T126, R157, N158, P159, C162, Y163, D165, T166, N187, R188, S189, R190, A191, C192, H193, P194, S196, P197, E207
antigen name:Receptor tyrosine-protein kinase erbB-2
host organism:Mus musculus BALB/c
antibody name:chA21
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
21680730 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1024759 |
| landingPage: |
http://www.iedb.org/assay/1974506 |
| type: |
Literature
|
| publicationVenue: |
J Biol Chem
|
| dates: |
2011
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Huihao Zhou
Zhao Zha
Yang Liu
Hongtao Zhang
Juanjuan Zhu
Siyi Hu
Guodong Shen
Liansheng Cheng
Liwen Niu
Mark I Greene
Maikun Teng
Jing Liu
|
| method: |
biological activity
|
| name: |
Structural insights into the down-regulation of overexpressed p185(her2/neu) protein of transformed cells by the antibody chA21.
|
| description: |
The epitope-specific chA21 mAb bound to p185(her2/neu) on the surface of the human mammary cancer cell line SK-BR-3 and down-regulated expression of p185(her2/neu). The scFv chA21 did not down-regulate p185(her2/neu), indicating the requirement for bivalency. MAb chA21 also down-regulated expression of EGFR and ErbB3, which form heterodimers with p185(her2/neu). MAb chA21 was also shown to form high molecular weight complexes with a p185(her2/neu) ectodomain-human Fc fusion protein.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
