Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1977958 |
| description: |
epitope description:S127, D163, N164, H231, S232, G233, G234, D235, L236, E237, I238, T318, D320, G321, G322, N323, D324, D325, N326, R332, G334, G335
antigen name:Envelope glycoprotein gp160
host organism:Homo sapiens
antibody name:CH103
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
23552890 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1025764 |
| landingPage: |
http://www.iedb.org/assay/1977958 |
| type: |
Literature
|
| publicationVenue: |
Nature
|
| dates: |
2013
|
| study type: | b cell assays |
| subject species: | HIV-1 M:C |
| fullName: |
Hua-Xin Liao
Rebecca Lynch
Tongqing Zhou
Feng Gao
S Munir Alam
Scott D Boyd
Andrew Z Fire
Krishna M Roskin
Chaim A Schramm
Zhenhai Zhang
Jiang Zhu
Lawrence Shapiro
NISC Comparative Sequencing Program
James C Mullikin
S Gnanakaran
Peter Hraber
Kevin Wiehe
Garnett Kelsoe
Guang Yang
Shi-Mao Xia
David C Montefiori
Robert Parks
Krissey E Lloyd
Richard M Scearce
Kelly A Soderberg
Myron Cohen
Gift Kamanga
Mark K Louder
Lillian M Tran
Yue Chen
Fangping Cai
Sheri Chen
Stephanie Moquin
Xiulian Du
M Gordon Joyce
Sanjay Srivatsan
Baoshan Zhang
Anqi Zheng
George M Shaw
Beatrice H Hahn
Thomas B Kepler
Bette T M Korber
Peter D Kwong
John R Mascola
Barton F Haynes
|
| method: |
biological activity
|
| name: |
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.
|
| description: |
The epitope-specific antibody CH103 neutralized heterologous HIV-1 clade B virus strains. CH103 was broadly neutralizing as shown by neutralization of 55% of a panel of 196 geographically and genetically diverse Env-pseudoviruses representing the major circulated genetic subtypes and circulating recombinant forms.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
