An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission.

Dataset

identifier:	1977812
description:	epitope description:N415, G523, T526 antigen name:Genome polyprotein host organism:Vicugna pacos antibody name:D03
aggregation:	instance of dataset
availability:	available
primaryPublications:	23553604

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1025767
landingPage:	http://www.iedb.org/assay/1977812

Publication

type:	Literature
publicationVenue:	Hepatology
dates:	2013

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus (isolate H77)

Person

fullName:	Alexander W Tarr Pierre Lafaye Luke Meredith Laurence Damier-Piolle Richard A Urbanowicz Annalisa Meola Jean-Luc Jestin Richard J P Brown Jane A McKeating Felix A Rey Jonathan K Ball Thomas Krey

Data Type

method:	immuno staining

Study

name:	An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission.
description:	The epitope of nanobody D03 on HCV E2 was determined by analysis of binding to alanine substitution mutants of E2 (between amino acids 412 and 621) expressed on HEK293T cells. Substitution at residues N415, G523 or T526 reduced binding by more than 50%.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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