An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission.

Dataset

identifier:	1977817
description:	epitope description:N415, G523, T526 antigen name:Genome polyprotein host organism:Vicugna pacos antibody name:D03
aggregation:	instance of dataset
availability:	available
primaryPublications:	23553604

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1025767
landingPage:	http://www.iedb.org/assay/1977817

Publication

type:	Literature
publicationVenue:	Hepatology
dates:	2013

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus (isolate H77)

Person

fullName:	Alexander W Tarr Pierre Lafaye Luke Meredith Laurence Damier-Piolle Richard A Urbanowicz Annalisa Meola Jean-Luc Jestin Richard J P Brown Jane A McKeating Felix A Rey Jonathan K Ball Thomas Krey

Data Type

method:	biological activity

Study

name:	An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission.
description:	The epitope-specific nanobody D03 neutralized HCV psuedo particles bearing glycoproteins of HCV genotypes 1b (UKN 1B12.16), 2a (UKN2A1.2) and 2b (UKN2B1.1), while 1a (H77, UKN1A20.8) and 3a (UKN3A13.6) were more resistant to neutralization.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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