An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission.

Dataset

identifier:	1977822
description:	epitope description:N415, G523, T526 antigen name:Genome polyprotein host organism:Vicugna pacos antibody name:D03
aggregation:	instance of dataset
availability:	available
primaryPublications:	23553604

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1025767
landingPage:	http://www.iedb.org/assay/1977822

Publication

type:	Literature
publicationVenue:	Hepatology
dates:	2013

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus (isolate H77)

Person

fullName:	Alexander W Tarr Pierre Lafaye Luke Meredith Laurence Damier-Piolle Richard A Urbanowicz Annalisa Meola Jean-Luc Jestin Richard J P Brown Jane A McKeating Felix A Rey Jonathan K Ball Thomas Krey

Data Type

method:	cross blocking

Study

name:	An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission.
description:	Binding of the epitope-specific nanobody D03 to HCV E2 was significantly inhibited by mAbs 1:7, AR1A and AR3A, suggesting that the epitope recognized by D03 overlaps the CD81 binding site. D03 was also shown to cross-compete with CD81 for binding to E2.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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