Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization.

Title:

Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization.

identifier:	1977832
description:	epitope description:L121, T280, N281, N282, A283, K284, S365, G366, G367, D368, E370, I371, N419, W421, G423, G425, Q426, T449, R450, D451, G452, G453, A454, N456, R463, G467, N468, K470, R474 antigen name:Envelope glycoprotein gp160 host organism:Homo sapiens antibody name:12A21
aggregation:	instance of dataset
availability:	available
primaryPublications:	23540694

study type:	b cell assays
subject species:	Human immunodeficiency virus 1

fullName:	Florian Klein Ron Diskin Johannes F Scheid Christian Gaebler Hugo Mouquet Ivelin S Georgiev Marie Pancera Tongqing Zhou Reha-Baris Incesu Brooks Zhongzheng Fu Priyanthi N P Gnanapragasam Thiago Y Oliveira Michael S Seaman Peter D Kwong Pamela J Bjorkman Michel C Nussenzweig

method:	ELISA

name:	Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization.
description:	The epitope residues were calculated from [PDB: 4JPW] as the antigen residues at 4 Å atomic distance from the antibody. Additional contact residue G124 is a replacement residue for a deleted loop. The epitope-specific antibody 3BNC117 bound to HIV-1 YU2 gp140. Reversion of all framework residues (FWR) or all FWR except gp120-contacting residues to germline reduced the binding affinity.

name:	iedb
homePage:	http://www.iedb.org

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.