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Title: IgE production to alpha-gal is accompanied by elevated levels of specific IgG1 antibodies and low amounts of IgE to blood group B.
identifier: 1977990
description:
epitope description:alpha-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-GlcpNAc-yl group
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 23390540
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1025519
landingPage: http://www.iedb.org/assay/1977990
type:
Literature
publicationVenue:
PLoS One
dates:
2013
study type: b cell assays
subject species: Bacteria
fullName:
Theo Rispens
Ninotska I L Derksen
Scott P Commins
Thomas A Platts-Mills
Rob C Aalberse
method:
ELISA
name:
IgE production to alpha-gal is accompanied by elevated levels of specific IgG1 antibodies and low amounts of IgE to blood group B.
description:
The IgG anti-epitope antibodies were found more frequently among B blood group negative than in B+ subjects, which were mostly negative, and in anti-epitope IgE+ compared to anti-epitope IgE- subjects. IgG1 is more frequently found in anti-epitope IgE+ subjects, while IgE– subjects have mainly IgG2 anti-epitope responses. The epitope competes with itself for binding by subject sera.

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