A specific antidote for dabigatran: functional and structural characterization. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

A specific antidote for dabigatran: functional and structural characterization.

Dataset

identifier:	1978011
description:	epitope description:dabigatran host organism:Mus musculus antibody name:anti-dabigatran
aggregation:	instance of dataset
availability:	available
primaryPublications:	23476049

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1025632
landingPage:	http://www.iedb.org/assay/1978011

Publication

type:	Literature
publicationVenue:	Blood
dates:	2013

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Felix Schiele Joanne van Ryn Keith Canada Corey Newsome Eliud Sepulveda John Park Herbert Nar Tobias Litzenburger

Data Type

method:	biological activity

Study

name:	A specific antidote for dabigatran: functional and structural characterization.
description:	The anti-dabigatran antibody Fab fragment (aDabi-Fab) prevented the prolonged clotting time induced by addition of the epitope in thrombin clotting assay. The aDabi-Fab mimics thrombin in recognition of the epitope, but does not exhibit thrombin-like enzymatic activity.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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