Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies.

Title:

Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies.

identifier:	1976155
description:	epitope description:QLINTNGSWHIN antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:hu5B3.v3
aggregation:	instance of dataset
availability:	available
primaryPublications:	23458406

study type:	b cell assays
subject species:	Hepatitis C virus

fullName:	Homer Pantua Jingyu Diao Mark Ultsch Meredith Hazen Mary Mathieu Krista McCutcheon Kentaro Takeda Shailesh Date Tommy K Cheung Qui Phung Phil Hass David Arnott Jo-Anne Hongo David J Matthews Alex Brown Arvind H Patel Robert F Kelley Charles Eigenbrot Sharookh B Kapadia

method:	x-ray crystallography

name:	Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies.
description:	The crystal structure of the neutralizing antibody Fab hu5B.v3 in complex with the epitope was determined. The epitope contained a C-terminal GSGK linker to biotin.

name:	iedb
homePage:	http://www.iedb.org

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