Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies.

Title:

Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies.

identifier:	1976156
description:	epitope description:QLINTNGSWHIN antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:MRCT10.v362
aggregation:	instance of dataset
availability:	available
primaryPublications:	23458406

study type:	b cell assays
subject species:	Hepatitis C virus

fullName:	Homer Pantua Jingyu Diao Mark Ultsch Meredith Hazen Mary Mathieu Krista McCutcheon Kentaro Takeda Shailesh Date Tommy K Cheung Qui Phung Phil Hass David Arnott Jo-Anne Hongo David J Matthews Alex Brown Arvind H Patel Robert F Kelley Charles Eigenbrot Sharookh B Kapadia

method:	surface plasmon resonance (SPR)

name:	Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies.
description:	The affinity of epitope-specific Fab MRCT10.v362 for the epitope was determined by surface plasmon resonance. The epitope contained a C-terminal GSGK linker to biotin. Alanine substitution of most positions was tolerated, except alanine substitution at position N4 (N415A) or W9 (W420A) abolished binding.

name:	iedb
homePage:	http://www.iedb.org

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.