Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies.

Title:

Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies.

identifier:	1976184
description:	epitope description:QLINTNGSWHIN antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:hu5B3.v3
aggregation:	instance of dataset
availability:	available
primaryPublications:	23458406

study type:	b cell assays
subject species:	Hepatitis C virus

fullName:	Homer Pantua Jingyu Diao Mark Ultsch Meredith Hazen Mary Mathieu Krista McCutcheon Kentaro Takeda Shailesh Date Tommy K Cheung Qui Phung Phil Hass David Arnott Jo-Anne Hongo David J Matthews Alex Brown Arvind H Patel Robert F Kelley Charles Eigenbrot Sharookh B Kapadia

method:	biological activity

name:	Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies.
description:	The epitope-specific antibody hu5B.v3 neutralized HCV genotype 2a (J6CF) and chimeric genotype 2a (Jc1; J6/C3). The humanized affinity matured antibody hu5B.v3 was more effective than the parent mouse antibody mu5B3. Mutations N417S, N417T and N415D in Jc1 HCVcc conferred resistance to neutralization, while mutation N417G remained sensitive.

name:	iedb
homePage:	http://www.iedb.org

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