Monoclonal anti-citrullinated protein antibodies selected on citrullinated fibrinogen have distinct targets with different cross-reactivity patterns.

Title:

Monoclonal anti-citrullinated protein antibodies selected on citrullinated fibrinogen have distinct targets with different cross-reactivity patterns.

Dataset

identifier:	1976211
description:	epitope description:RPAPPPISGGGYRAR + CITR(R1, R13, R15) antigen name:Fibrinogen beta chain host organism:Homo sapiens antibody name:cFib1.2
aggregation:	instance of dataset
availability:	available
primaryPublications:	23264551

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1025642
landingPage:	http://www.iedb.org/assay/1976211

Publication

type:	Literature
publicationVenue:	Rheumatology (Oxford)
dates:	2013

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Lotte A van de Stadt Pauline A van Schouwenburg Suzanne Bryde Simone Kruithof Dirkjan van Schaardenburg Dö rte Hamann Gertjan Wolbink Theo Rispens

Data Type

method:	surface plasmon resonance (SPR)

Study

name:	Monoclonal anti-citrullinated protein antibodies selected on citrullinated fibrinogen have distinct targets with different cross-reactivity patterns.
description:	The epitope sequence was cited in van de Stadt et al. Ann Rheum Dis. 2011 Jan 70(1):128-33. doi: 10.1136/ard.2010.132662 [PMID:21062853]. The epitope-specific mAb recognized the citrullinated protein, but not the non-citrullinated protein in SPR.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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