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Title: Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihydrofolate reductase of Escherichia coli.
identifier: 1989259
description:
epitope description:V10, D11, H114, I115, D116, E118, F140, S150, Y151, C152
antigen name:Dihydrofolate reductase (UniProt:P0ABQ4)
host organism:Lama glama
antibody name:Nb113
aggregation:
instance of dataset
availability:
available
primaryPublications: 23911607
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1026659
landingPage: http://www.iedb.org/assay/1989259
type:
Literature
publicationVenue:
Biochim Biophys Acta
dates:
2013
study type: b cell assays
subject species: Escherichia coli K-12
fullName:
David Oyen
Rainer Wechselberger
Vasundara Srinivasan
Jan Steyaert
John N Barlow
method:
x-ray crystallography
name:
Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihydrofolate reductase of Escherichia coli.
description:
The epitope of nanobody Nb113 on DHFR:folate was determined from the crystal structure of the complex. There are two complexes in the asymmetric unit.

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