Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1989313 |
| description: |
epitope description:E17, N18, A19, M20, P21, W22, N23, L28, F31, E48, S49, I50, R52, L54, A145, Q146
antigen name:Dihydrofolate reductase (UniProt:P0ABQ4)
host organism:Lama glama
antibody name:Ca1698
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
23911607 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1026659 |
| landingPage: |
http://www.iedb.org/assay/1989313 |
| type: |
Literature
|
| publicationVenue: |
Biochim Biophys Acta
|
| dates: |
2013
|
| study type: | b cell assays |
| subject species: | Escherichia coli K-12 |
| fullName: |
David Oyen
Rainer Wechselberger
Vasundara Srinivasan
Jan Steyaert
John N Barlow
|
| method: |
nuclear magnetic resonance (NMR)
|
| name: |
Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihydrofolate reductase of Escherichia coli.
|
| description: |
The epitope region on DHFR bound by epitope-specific nanobody Ca1698 was mapped by chemical shift perturbation NMR. Nanobody Ca1698 bound to residues in a widely dispersed region of the folate binding site.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
