Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1989465 |
| description: |
epitope description:R28, R29, E51, A54, V70, E73, L95, S96, D98, E115, R141, W157, W183, N185, A201, P225, H226, F228, W242, S243, F266, M269
antigen name:Low-density lipoprotein receptor-related protein 6
host organism:Homo sapiens
antibody name:YW210.09
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
21944579 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1026757 |
| landingPage: |
http://www.iedb.org/assay/1989465 |
| type: |
Literature
|
| publicationVenue: |
Structure
|
| dates: |
2011
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Eric Bourhis
Weiru Wang
Christine Tam
Jiyoung Hwang
Yingnan Zhang
Didier Spittler
Oscar W Huang
Yan Gong
Alberto Estevez
Inna Zilberleyb
Lionel Rouge
Cecilia Chiu
Yan Wu
Mike Costa
Rami N Hannoush
Yvonne Franke
Andrea G Cochran
|
| method: |
x-ray crystallography
|
| name: |
Wnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5/6.
|
| description: |
The epitope residues were calculated from [PDB: 3SOB] as the antigen residues at 4Å
atomic distance from the antibody.
The epitope of YW210.09 Fab on low density lipoprotein receptor 6 (LRP6) E1 domain was determined from the crystal structure of the complex, solved by molecular replacement. The Fab was crystallized with the first two tandem ß-propeller-EGF-like domains of LRP6 (E1E2), but after extended incubation E2 was degraded. The antibody binds to a region at the top center of the ß-propeller.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
