Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1989496 |
| description: |
epitope description:P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
antigen name:Epidermal growth factor receptor
host organism:Mus musculus BALB/c
antibody name:cetuximab (C225)
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
23791944 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1026704 |
| landingPage: |
http://www.iedb.org/assay/1989496 |
| type: |
Literature
|
| publicationVenue: |
Structure
|
| dates: |
2013
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Karl R Schmitz
Atrish Bagchi
Rob C Roovers
Paul M P van Bergen en Henegouwen
Kathryn M Ferguson
|
| method: |
biological activity
|
| name: |
Structural evaluation of EGFR inhibition mechanisms for nanobodies/VHH domains.
|
| description: |
The epitope residues were calculated from [PDB: 4KRP] as the antigen residues at 4Å
atomic distance from the antibody. The epitope calculated from [PDB: 4KRO] misses two residues V350 and Q411.
The epitope-specific mAb cetuximab (C225) reduced EGF binding by the soluble EGF Receptor extracellular region.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
