Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1026710 |
| landingPage: |
http://www.iedb.org/assay/1989989 |
| type: |
Literature
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| publicationVenue: |
J Virol
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| dates: |
2013
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| study type: | b cell assays |
| subject species: | Human enterovirus 71 Subgenogroup C2 |
| fullName: |
Hyunwook Lee
Javier O Cifuente
Robert E Ashley
James F Conway
Alexander M Makhov
Yoshio Tano
Hiroyuki Shimizu
Yorihiro Nishimura
Susan Hafenstein
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| method: |
biological activity
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| name: |
A strain-specific epitope of enterovirus 71 identified by cryo-electron microscopy of the complex with fab from neutralizing antibody.
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| description: |
The epitope residues recognized by Mab MA28-7 were deduced based on the ability to neutralize different strains of enterovirus 71 (EV71) in a standard micro-neutralization assay using Vero cells. Mab MA28-7 neutralized EV71 strains C7/Osaka (genotype B4), SK-EV006 (genotype B3) and 1095/Shiga (genotype C2). It did not neutralize EV71 strains Nagoya (genotype B1), Bulgaria (genotype B1) or BrCr/tr (genotype A). Within the MA28-7-binding footprint VP1, only the epitope residues, especially Gly-145, were conserved among the neutralization-sensitive strains.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
