The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein.

Dataset

identifier:	1990297
description:	epitope description:I138, H139, F140, G141, N142, D143, W144, E145, D146, R147, M204, V208, M212 antigen name:Major prion protein host organism:Mus musculus PrP null
aggregation:	instance of dataset
availability:	available
primaryPublications:	23903654

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1026656
landingPage:	http://www.iedb.org/assay/1990297

Publication

type:	Literature
publicationVenue:	Nature
dates:	2013

Dimension

study type:	b cell assays
subject species:	Mus musculus

Person

fullName:	Tiziana Sonati Regina R Reimann Jeppe Falsig Pravas Kumar Baral Tracy O'Connor Simone Hornemann Sine Yaganoglu Bei Li Uli S Herrmann Barbara Wieland Mridula Swayampakula Muhammad Hafizur Rahman Dipankar Das Nat Kav Roland Riek Pawel P Liberski Michael N G James Adriano Aguzzi

Data Type

method:	in vivo assay

Study

name:	The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein.
description:	Injection of the epitope-specific antibody POM1 induced lesions in the of cerebella starting 4-72 h after injection into WT or tga20 mice. Injection of POM1 into Prnp(o/o) mice had no effect, confirming the requirement for PrP expression.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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