The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein.

Dataset

identifier:	1990300
description:	epitope description:GQPHGGGW antigen name:Major prion protein host organism:Mus musculus PrP null antibody name:POM2
aggregation:	instance of dataset
availability:	available
primaryPublications:	23903654

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1026656
landingPage:	http://www.iedb.org/assay/1990300

Publication

type:	Literature
publicationVenue:	Nature
dates:	2013

Dimension

study type:	b cell assays
subject species:	Mus musculus

Person

fullName:	Tiziana Sonati Regina R Reimann Jeppe Falsig Pravas Kumar Baral Tracy O'Connor Simone Hornemann Sine Yaganoglu Bei Li Uli S Herrmann Barbara Wieland Mridula Swayampakula Muhammad Hafizur Rahman Dipankar Das Nat Kav Roland Riek Pawel P Liberski Michael N G James Adriano Aguzzi

Data Type

method:	surface plasmon resonance (SPR)

Study

name:	The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein.
description:	The epitope sequence GQPHGG(G/S)W is repeated in the PrP sequence at residues 57-64, 64-72, 72-80 and 80-88. The affinity of epitope-specific POM2 Fab for binding to mouse PrP (23-230) was determined by surface plasmon resonance. The affinity of POM2 scFv for mouse PrP (23-230) was KD = 20 nM.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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