Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1997000 |
| description: |
epitope description:C118, V119, L121, V196, G319, D320, I321, R322, Q323, D363, P364, V367, T368, Y379, N381, P404, C405, R406, I407, K408, Q409, I410, N412, K419, M421, Y422, A423, P424, R427
antigen name:Envelope glycoprotein gp160
host organism:Lama glama
antibody name:JM4
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
23843638 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1026660 |
| landingPage: |
http://www.iedb.org/assay/1997000 |
| type: |
Literature
|
| publicationVenue: |
J Virol
|
| dates: |
2013
|
| study type: | b cell assays |
| subject species: | Human immunodeficiency virus type 1 (isolate YU2) |
| fullName: |
Priyamvada Acharya
Timothy S Luongo
Ivelin S Georgiev
Julie Matz
Stephen D Schmidt
Mark K Louder
Pascal Kessler
Yongping Yang
Krisha McKee
Sijy O'Dell
Lei Chen
Daniel Baty
Patrick Chames
Loï
c Martin
John R Mascola
Peter D Kwong
|
| method: |
x-ray crystallography
|
| name: |
Heavy chain-only IgG2b llama antibody effects near-pan HIV-1 neutralization by recognizing a CD4-induced epitope that includes elements of coreceptor- and CD4-binding sites.
|
| description: |
The epitope of JM4 VHH on the HIV gp120 core complexed with a CD4 mimetic miniprotein M48U1 was determined from the crystal structure of the complex, solved by molecular replacement. There are four complexes in the asymmetric unit. The gp120 core protein had deletions of the V1/V2 and V3 loop regions. JM4 did not interact with the CD4 mimetic M48U1.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
