Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1997014 |
| description: |
epitope description:C118, V119, L121, V196, G319, D320, I321, R322, Q323, D363, P364, V367, T368, Y379, N381, P404, C405, R406, I407, K408, Q409, I410, N412, K419, M421, Y422, A423, P424, R427
antigen name:Envelope glycoprotein gp160
host organism:Lama glama
antibody name:JM4
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
23843638 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1026660 |
| landingPage: |
http://www.iedb.org/assay/1997014 |
| type: |
Literature
|
| publicationVenue: |
J Virol
|
| dates: |
2013
|
| study type: | b cell assays |
| subject species: | Human immunodeficiency virus type 1 (isolate YU2) |
| fullName: |
Priyamvada Acharya
Timothy S Luongo
Ivelin S Georgiev
Julie Matz
Stephen D Schmidt
Mark K Louder
Pascal Kessler
Yongping Yang
Krisha McKee
Sijy O'Dell
Lei Chen
Daniel Baty
Patrick Chames
Loï
c Martin
John R Mascola
Peter D Kwong
|
| method: |
biological activity
|
| name: |
Heavy chain-only IgG2b llama antibody effects near-pan HIV-1 neutralization by recognizing a CD4-induced epitope that includes elements of coreceptor- and CD4-binding sites.
|
| description: |
The epitope-specific antibody JM4 VHH neutralized a broad range (60%) of HIV-1 isolates from different clades, using a panel of 30 HIV isolates. Conversion of JM4 VHH into an IgG2b or IgG3 format increased the neutralization breadth and potency. JM4-IgG2b neutralized 96% of a panel of 195 HIV-1 isolates. Glycosylation at residue Asn386 did not affect neutralization by JM4.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
