Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 2000486 |
| description: |
epitope description:E36, S37, H38, V39, A40, R41, A42, N43, L63, K64, N65, N66, N67, R68, V70, W78
antigen name:Stromal cell-derived factor 1
host organism:Cricetulus migratorius
antibody name:30D8
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
23812669 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1026658 |
| landingPage: |
http://www.iedb.org/assay/2000486 |
| type: |
Literature
|
| publicationVenue: |
Clin Cancer Res
|
| dates: |
2013
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Cuiling Zhong
Jianyong Wang
Bing Li
Hong Xiang
Mark Ultsch
Mary Coons
Terence Wong
Nancy Y Chiang
Suzy Clark
Robyn Clark
Leah Quintana
Peter Gribling
Eric Suto
Kai Barck
Racquel Corpuz
Jenny Yao
Rashi Takkar
Wyne P Lee
Lisa A Damico-Beyer
Richard D Carano
Camellia Adams
Robert F Kelley
Weiru Wang
Napoleone Ferrara
|
| method: |
biological activity
|
| name: |
Development and preclinical characterization of a humanized antibody targeting CXCL12.
|
| description: |
The epitope residues were calculated from [PDB: 4LMQ] as the antigen residues at 4Å
atomic distance from the antibody.
The epitope-specific humanized 30D8 antibody and the parent mouse 30D8 mAb neutralized the activity of human CXCL12alpha, as shown by inhibition of CXCL12alpha-induced Jurakat cell migration. The mouse 30D8 mAb was also shown to block CXCL12alpha binding to 293-CXCR4 or 293-CXCR7 cells and blocked CXCL12alpha-induced Rac1 activation.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
