Phl p 1-specific human monoclonal IgE and design of a hypoallergenic group 1 grass pollen allergen fragment.

Title:

Phl p 1-specific human monoclonal IgE and design of a hypoallergenic group 1 grass pollen allergen fragment.

identifier:	2000497
description:	epitope description:K176, N179, D223 antigen name:Phl p 1 host organism:Homo sapiens antibody name:1p1:8
aggregation:	instance of dataset
availability:	available
primaryPublications:	23761636

study type:	b cell assays
subject species:	Phleum pratense

fullName:	Mattias Levin Frida Rydnert Eva Kä llströ m Lor Wai Tan Peter J Wormald Malin Lindstedt Lennart Greiff Mats Ohlin

method:	antigen inhibition

name:	Phl p 1-specific human monoclonal IgE and design of a hypoallergenic group 1 grass pollen allergen fragment.
description:	The C-terminal domain of PhI p1 was able to inhibit binding of the epitope-specific scFv construct to the same protein fragment. A construct containing the K176A, N179A, and D223A mutation was not able to inhibit antibody binding. The epitiope-specific scFv construct also recognized the C-terminal domain of PhI p1 in ELISA.

name:	iedb
homePage:	http://www.iedb.org

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