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Title: Carrier protein influences immunodominance of a known epitope: implication in peptide vaccine design.
identifier: 2000557
description:
epitope description:SPITDTNLDTMDKKKISQAVHAAHAEINEAGR
host organism:Mus musculus BALB/c
aggregation:
instance of dataset
availability:
available
primaryPublications: 23928464
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1026790
landingPage: http://www.iedb.org/assay/2000557
type:
Literature
publicationVenue:
Vaccine
dates:
2013
study type: b cell assays
subject species:
fullName:
Moumita Ghosh
Ashish K Solanki
Koushik Roy
Reema R Dhoke
Ashish
Syamal Roy
method:
ELISA
name:
Carrier protein influences immunodominance of a known epitope: implication in peptide vaccine design.
description:
The epitope is a combination of the OVA peptide (323-339) and the P. yoelii AMA-1 peptide SPITBTNLBTMBK, wherein the B residues represent aspartic acid (D). The replacement of these residues is not part of the natural P. yoelii AMA-1 sequence.
Sera from mice immunized with the epitope minimally recognized the PY AMA-1 peptide.

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