Cerebrospinal Abeta11-x and 17-x levels as indicators of mild cognitive impairment and patients' stratification in Alzheimer's disease.

Title:

Cerebrospinal Abeta11-x and 17-x levels as indicators of mild cognitive impairment and patients' stratification in Alzheimer's disease.

identifier:	2000957
description:	epitope description:GLMVGGVVIA antigen name:Amyloid beta A4 protein host organism:Mus musculus CD1 antibody name:12E8
aggregation:	instance of dataset
availability:	available
primaryPublications:	23860482

study type:	b cell assays
subject species:	Homo sapiens

fullName:	J-D Abraham S Promé N Salvetat L Rubrecht S Cobo E du Paty P Galé a E Mathieu-Dupas S Ranaldi C Caillava G-A Cré mer F Rieunier P Robert F Molina D Laune F Checler J Fareh

method:	binding assay

name:	Cerebrospinal Abeta11-x and 17-x levels as indicators of mild cognitive impairment and patients' stratification in Alzheimer's disease.
description:	The epitope-specific mAb recognized the A beta 11-42 and A beta 17-42 in multiplex assay (EZ-link Micro Biotinylation Ki, Pierce). The secretion of Abeta11-42 was strongly increased in the supernatant of HEK293 cells that express wild type AbetaPP and BACE1 (APPwt+BACE1) and decreased in supernatants of HEK293 cells that express Swedish mutant AbetaPP (APPsw) in comparison to cells that express wild type AbetaPP (APPwt); the concentration of Abeta17-42 peptides was decreased in the supernatants of HEK293 APPwt+BACE1 or APPsw cells in comparison to APPwt cells.

name:	iedb
homePage:	http://www.iedb.org

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