A neutralizing monoclonal antibody targeting the acid-sensitive region in chikungunya virus E2 protects from disease.

Title:

A neutralizing monoclonal antibody targeting the acid-sensitive region in chikungunya virus E2 protects from disease.

identifier:	2004510
description:	epitope description:A487 antigen name:Structural polyprotein host organism:Homo sapiens antibody name:C9
aggregation:	instance of dataset
availability:	available
primaryPublications:	24069479

study type:	b cell assays
subject species:	Chikungunya virus

fullName:	Suganya Selvarajah Nicole R Sexton Kristen M Kahle Rachel H Fong Kimberly-Anne Mattia Joy Gardner Kai Lu Nathan M Liss Beatriz Salvador David F Tucker Trevor Barnes Manu Mabila Xiangdong Zhou Giada Rossini Joseph B Rucker David Avram Sanders Andreas Suhrbier Vittorio Sambri Alain Michault Marcus O Muench Benjamin J Doranz Graham Simmons

method:	biological activity

name:	A neutralizing monoclonal antibody targeting the acid-sensitive region in chikungunya virus E2 protects from disease.
description:	The epitope -specific mAb was able to neutralize the CHIKV pseudoviruses bearing an envelope from the S27 strain with an IC50 of 0.1 ug/ml. The mAb also neutralized CHIKV envelopes with a naturally occurring mutation at a critical site near the fusion loop in E1 (A226V) that is associated with increased CHIKV infectivity for, and transmission by, the mosquito vector.

name:	iedb
homePage:	http://www.iedb.org

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