Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 2004656 |
| description: |
epitope description:R331, Q332, I333, G334, A335, S336, L337, N338, D339, A327, Q328, K368, Y369, R426, I446, G448,D449, R469
antigen name:Hepatocyte growth factor receptor
host organism:Mus musculus BALB/c
antibody name:Onartuzumab
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
23882082 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1026758 |
| landingPage: |
http://www.iedb.org/assay/2004656 |
| type: |
Literature
|
| publicationVenue: |
Proc Natl Acad Sci U S A
|
| dates: |
2013
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Mark Merchant
Xiaolei Ma
Henry R Maun
Zhong Zheng
Jing Peng
Mally Romero
Arthur Huang
Nai-ying Yang
Merry Nishimura
Joan Greve
Lydia Santell
Yu-Wen Zhang
Yanli Su
Dafna W Kaufman
Karen L Billeci
Elaine Mai
Barbara Moffat
Amy Lim
Eileen T Duenas
Heidi S Phillips
Hong Xiang
Judy C Young
George F Vande Woude
Mark S Dennis
Dorothea E Reilly
Ralph H Schwall
Melissa A Starovasnik
Robert A Lazarus
Daniel G Yansura
|
| method: |
biological activity
|
| name: |
Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent.
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| description: |
The epitope-specific antibody onartuzumab inhibits HGF binding to the HGF receptor (MET) more potently than the parent murine/human chimeric antibody chOA5D5. Onartuzumab blocks HGF-alpha, but not HGF-ß, binding to HGF receptor MET. Onartuzumab inhibits HGF-dependent MET phosphorylation and downstream signalling in A549 cells and inhibits HGF-dependent cell proliferation in Ba/F3-huMET cells and other cancer cell lines.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
