Nature-inspired design of motif-specific antibody scaffolds. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Nature-inspired design of motif-specific antibody scaffolds.

Dataset

identifier:	2004915
description:	epitope description:RREILSRRPSYRKILNDL + PHOS(S10) antigen name:Cyclic AMP-responsive element-binding protein 1 (UniProt:E7EWP8) host organism:Mus musculus antibody name:P5.G10
aggregation:	instance of dataset
availability:	available
primaryPublications:	23955275

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1026708
landingPage:	http://www.iedb.org/assay/2004915

Publication

type:	Literature
publicationVenue:	Nat Biotechnol
dates:	2013

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	James T Koerber Nathan D Thomsen Brett T Hannigan William F Degrado James A Wells

Data Type

method:	ELISA

Study

name:	Nature-inspired design of motif-specific antibody scaffolds.
description:	The affinity of the phospho-epitope-specific scFv-Fc fusion protein for binding to the pSer containing epitope was determined by competition ELISA. Epitope-selected scFv bound specifically to the phosphorylated epitope and not to the unphosphorylated peptide or to other unrelated phosphopeptides.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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