Cross-neutralization of four paramyxoviruses by a human monoclonal antibody. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Cross-neutralization of four paramyxoviruses by a human monoclonal antibody.

Dataset

identifier:	2006430
description:	epitope description:T50, L305, G307, I309, D310 antigen name:Fusion protein (F) host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	23955151

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1026832
landingPage:	http://www.iedb.org/assay/2006430

Publication

type:	Literature
publicationVenue:	Nature
dates:	2013

Dimension

study type:	b cell assays
subject species:	Human respiratory syncytial virus A2

Person

fullName:	Davide Corti Siro Bianchi Fabrizia Vanzetta Andrea Minola Laurent Perez Gloria Agatic Barbara Guarino Chiara Silacci Jessica Marcandalli Benjamin J Marsland Antonio Piralla Elena Percivalle Federica Sallusto Fausto Baldanti Antonio Lanzavecchia

Data Type

method:	in vivo assay

Study

name:	Cross-neutralization of four paramyxoviruses by a human monoclonal antibody.
description:	The epitope-specific mAb was able to protect mice when given before intranasal infection with HRSV A/A2/61. The mAb was also shown to decrease lung viral titers and decrease TNF IL-6 and IFN-g in lungs compared to control antibodies.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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