Synthetic dimeric Abeta(28-40) mimics the complex epitope of human anti-Abeta autoantibodies against toxic Abeta oligomers.

Title:

Synthetic dimeric Abeta(28-40) mimics the complex epitope of human anti-Abeta autoantibodies against toxic Abeta oligomers.

identifier:	2006239
description:	epitope description:KGAIIGLMVGGVV antigen name:Amyloid beta A4 protein host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	23846683

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Andreas M Roeder Yvonne Roettger Anne Stü ndel Richard Dodel Armin Geyer

method:	surface plasmon resonance (SPR)

name:	Synthetic dimeric Abeta(28-40) mimics the complex epitope of human anti-Abeta autoantibodies against toxic Abeta oligomers.
description:	Naturally occurring antibodies that were purified using a column which was composed of the miniamyloid 9a (containing the epitope dimer plus a C-terminal cysteine), recognized different oligomeric forms of the epitope that contained two properly aligned A beta (28–40) peptides (miniamyloids) conjugated to Lys as the branching amino acid and separated by ε-aminohexanoic acid (KGAIIGLMVGGVVK-Ahx-KKK-Ahx). Only the peptides with C-terminal cationic charges showed good activities.

name:	iedb
homePage:	http://www.iedb.org

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