Analysis of cross-reactive antibodies recognizing the fusion loop of envelope protein and correlation with neutralizing antibody titers in Nicaraguan dengue cases.

Title:

Analysis of cross-reactive antibodies recognizing the fusion loop of envelope protein and correlation with neutralizing antibody titers in Nicaraguan dengue cases.

Dataset

identifier:	2006448
description:	epitope description:W101, F108 antigen name:Genome polyprotein host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	24069496

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1026823
landingPage:	http://www.iedb.org/assay/2006448

Publication

type:	Literature
publicationVenue:	PLoS Negl Trop Dis
dates:	2013

Dimension

study type:	b cell assays
subject species:	Dengue virus type 1 Hawaii

Person

fullName:	Chih-Yun Lai Katherine L Williams Yi-Chieh Wu Sarah Knight Angel Balmaseda Eva Harris Wei-Kung Wang

Data Type

method:	ELISA

Study

name:	Analysis of cross-reactive antibodies recognizing the fusion loop of envelope protein and correlation with neutralizing antibody titers in Nicaraguan dengue cases.
description:	Anti-Env fusion loop (FL) antibody levels were determined by testing human sera against VLPs containing FL mutations at residues W101 and F108 as well as wild type VLPs. The portion of anti-FL antibodies was determined by calculating [1-mutant VLP titer/wildtype titer ]100. This included primary and secondary infections.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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