Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 2006808 |
| description: |
epitope description:E238, P249, T250, L260, D261, R263, V265, E266, T267, C268, P269, P270, P271, Y272, H274, N308, N309
antigen name:Insulin receptor
host organism:Mus musculus BALB/c
antibody name:83-7
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
23302862 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1026763 |
| landingPage: |
http://www.iedb.org/assay/2006808 |
| type: |
Literature
|
| publicationVenue: |
Nature
|
| dates: |
2013
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
John G Menting
Jonathan Whittaker
Mai B Margetts
Linda J Whittaker
Geoffrey K-W Kong
Brian J Smith
Christopher J Watson
Lenka Zá
ková
Emí
lia Kletví
Jiří
Jirá
ček
Shu Jin Chan
Donald F Steiner
Guy G Dodson
Andrzej M Brzozowski
Michael A Weiss
Colin W Ward
Michael C Lawrence
|
| method: |
x-ray crystallography
|
| name: |
How insulin engages its primary binding site on the insulin receptor.
|
| description: |
The epitope residues were calculated from [PDB: 3W11] as the antigen residues at 4Å
atomic distance from the antibody.
The epitope of Fab 83-7 on the insulin receptor ectodomain was determined from the crystal structure of complex C of Fab 83-7 in complex with the insulin receptor L1-CR construct IR310.T + alphaCT(697-719) bound to high-affinity insulin analogue [D-Pro-B26]-DTI-NH2. Fab 83-7 binds to insulin receptor at the CR (cysteine-rich) domain.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
