Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 2007431 |
| description: |
epitope description:K96, L121, T122, T259, T280, N281, N282, A283, K284, S365, G366, G367, D368, E370, I371, N419, M420, W421, T424, G425, Q426, T449, R450, D451, G452, G453, A454, N455, N459, E460, T461, R463, G465, N468
antigen name:Envelope glycoprotein gp160
host organism:Homo sapiens
antibody name:VRC-PG20
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
23911655 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1026761 |
| landingPage: |
http://www.iedb.org/assay/2007431 |
| type: |
Literature
|
| publicationVenue: |
Immunity
|
| dates: |
2013
|
| study type: | b cell assays |
| subject species: | Human immunodeficiency virus 1 |
| fullName: |
Tongqing Zhou
Jiang Zhu
Xueling Wu
Stephanie Moquin
Baoshan Zhang
Priyamvada Acharya
Ivelin S Georgiev
Han R Altae-Tran
Gwo-Yu Chuang
M Gordon Joyce
Young Do Kwon
Nancy S Longo
Mark K Louder
Timothy Luongo
Krisha McKee
Chaim A Schramm
Jeff Skinner
Yongping Yang
Zhongjia Yang
Zhenhai Zhang
Anqi Zheng
Mattia Bonsignori
Barton F Haynes
Johannes F Scheid
Michel C Nussenzweig
Melissa Simek
Dennis R Burton
Wayne C Koff
NISC Comparative Sequencing Program
James C Mullikin
Mark Connors
Lawrence Shapiro
Gary J Nabel
John R Mascola
Peter D Kwong
|
| method: |
surface plasmon resonance (SPR)
|
| name: |
Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies.
|
| description: |
The epitope residues were calculated from [PDB: 4LSU] as the antigen residues at 4 Å
atomic distance from the antibody. An additional contact residue G124 in PDB is one of the residues substituted for the V1/V2 loop in the GenBank sequence and is mapped to N199 in the GenBank sequence.
The affinity of epitope-specific antibody VRC-PG20 for HIV-1 gp120 was determined by surface plasmon resonance.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
