Ligand recognition by anti-DNA autoantibodies. Affinity, specificity, and mode of binding. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Ligand recognition by anti-DNA autoantibodies. Affinity, specificity, and mode of binding.

Dataset

identifier:	2007364
description:	epitope description:dT5 host organism:Mus musculus MLR/lpr antibody name:15D8, 9F11, 15B10, 8D8, 11F8
aggregation:	instance of dataset
availability:	available
primaryPublications:	8634294

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1006970
landingPage:	http://www.iedb.org/assay/2007364

Publication

type:	Literature
publicationVenue:	Biochemistry
dates:	1996

Dimension

study type:	b cell assays
subject species:

Person

fullName:	P C Swanson C Ackroyd G D Glick

Data Type

method:	biological activity

Study

name:	Ligand recognition by anti-DNA autoantibodies. Affinity, specificity, and mode of binding.
description:	The epitope -specific mAbs bound the antigen, as shown by a gel shift assay. MAbs 15D8, 9F11, 15B10 are IgG2b, 8D8 is IgG2a, and 11F8 is IgG3. Binding of dT21 by the IgG2b mAbs (e.g., 15D8) and by 11F8 does not appear to be affected by changes in ionic strength, whereas the other IgG2a mAbs (e.g., 4B2) show a small dependence in Kd upon varying [Na+].

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.