Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 2007228 |
| description: |
epitope description:N278, T280, N281, N282, A283, K284, N355, S365, G366, G367, D368, I371, T449, R450, D451, G452, G453, A454, N455, N456
antigen name:Envelope glycoprotein gp160
host organism:Homo sapiens
antibody name:VRC-CH31
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
23911655 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1026761 |
| landingPage: |
http://www.iedb.org/assay/2007228 |
| type: |
Literature
|
| publicationVenue: |
Immunity
|
| dates: |
2013
|
| study type: | b cell assays |
| subject species: | Human immunodeficiency virus 1 |
| fullName: |
Tongqing Zhou
Jiang Zhu
Xueling Wu
Stephanie Moquin
Baoshan Zhang
Priyamvada Acharya
Ivelin S Georgiev
Han R Altae-Tran
Gwo-Yu Chuang
M Gordon Joyce
Young Do Kwon
Nancy S Longo
Mark K Louder
Timothy Luongo
Krisha McKee
Chaim A Schramm
Jeff Skinner
Yongping Yang
Zhongjia Yang
Zhenhai Zhang
Anqi Zheng
Mattia Bonsignori
Barton F Haynes
Johannes F Scheid
Michel C Nussenzweig
Melissa Simek
Dennis R Burton
Wayne C Koff
NISC Comparative Sequencing Program
James C Mullikin
Mark Connors
Lawrence Shapiro
Gary J Nabel
John R Mascola
Peter D Kwong
|
| method: |
x-ray crystallography
|
| name: |
Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies.
|
| description: |
The epitope residues were calculated from [PDB: 4LSP] as the antigen residues at 4Å
atomic distance from the antibody.
The epitope of broadly and potently neutralizing antibody VRC-CH31 Fab on HIV-1 gp120 core from clade A/E 93TH057 was determined from the crystal structure of the complex. The HIV-1 gp120 core contains truncations in the variable V1/V2 and V3 loops as well as the N- and C-termini.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
