A unique and conserved neutralization epitope in H5N1 influenza viruses identified by an antibody against the A/Goose/Guangdong/1/96 hemagglutinin.

Title:

A unique and conserved neutralization epitope in H5N1 influenza viruses identified by an antibody against the A/Goose/Guangdong/1/96 hemagglutinin.

Dataset

identifier:	2008532
description:	epitope description:G62, N61, V63, P65, R69, E85, N88, E91, P90, H126, E128, Y287, N289, N291 antigen name:Hemagglutinin host organism:Mus musculus antibody name:H5M9
aggregation:	instance of dataset
availability:	available
primaryPublications:	24049169

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1026859
landingPage:	http://www.iedb.org/assay/2008532

Publication

type:	Literature
publicationVenue:	J Virol
dates:	2013

Dimension

study type:	b cell assays
subject species:	Influenza A virus (A/goose/Guangdong/1/1996(H5N1))

Person

fullName:	Xueyong Zhu Yong-Hui Guo Tao Jiang Ya-Di Wang Kwok-Hung Chan Xiao-Feng Li Wenli Yu Ryan McBride James C Paulson Kwok-Yung Yuen Cheng-Feng Qin Xiao-Yan Che Ian A Wilson

Data Type

method:	in vivo assay

Study

name:	A unique and conserved neutralization epitope in H5N1 influenza viruses identified by an antibody against the A/Goose/Guangdong/1/96 hemagglutinin.
description:	Epitope residues were calculated from [PDB: 4MHJ] as the antigen residues at 4 Å atomic distance from the antibody. Prophylactic administration of the epitope-specific H5M9 IgG protected 100% of the mice from lethal challenge with influenza A virus (A/Vietnam/1194/2004(H5N1)) and prevented weight loss. In the therapeutic model, a single dose of 20 mg/kg H5M9 provided 66.7% protection and mice showed recovery in body weight after initial infection.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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