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Title: Redefining an epitope of a malaria vaccine candidate, with antibodies against the N-terminal MSA-2 antigen of Plasmodium harboring non-natural peptide bonds.
identifier: 2007646
description:
epitope description:KNESKYSNTFINNAYNMSIR + MCM(I11, N12)
host organism:Mus musculus BALB/c
aggregation:
instance of dataset
availability:
available
primaryPublications: 23836419
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1026834
landingPage: http://www.iedb.org/assay/2007646
type:
Literature
publicationVenue:
Amino Acids
dates:
2013
study type: b cell assays
subject species:
fullName:
José
Manuel Lozano
Yuly Andrea Guerrero
Martha Patricia Alba
Liliana Patricia Lesmes
José
Oswaldo Escobar
Manuel Elkin Patarroyo
method:
in vivo assay
name:
Redefining an epitope of a malaria vaccine candidate, with antibodies against the N-terminal MSA-2 antigen of Plasmodium harboring non-natural peptide bonds.
description:
In the epitope, the amide type peptide bond (CO-NH) was substituted with its reduced amide isotere bond psi-(CH2-NH) between residues Ile11 and Asn12.
Passive transfer of the epitope-specific mAbs into mice infected with P. yoelii resulted in a delay in the emergence of significant percentages of parasitemia, enabled the animals to manage higher parasitemia levels and prolonged survival.

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