Redefining an epitope of a malaria vaccine candidate, with antibodies against the N-terminal MSA-2 antigen of Plasmodium harboring non-natural peptide bonds.

Title:

Redefining an epitope of a malaria vaccine candidate, with antibodies against the N-terminal MSA-2 antigen of Plasmodium harboring non-natural peptide bonds.

Dataset

identifier:	2007648
description:	epitope description:KNESKYSNTFINNAYNMSIR + MCM(I11, N12) host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	23836419

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1026834
landingPage:	http://www.iedb.org/assay/2007648

Publication

type:	Literature
publicationVenue:	Amino Acids
dates:	2013

Dimension

study type:	b cell assays
subject species:

Person

fullName:	José Manuel Lozano Yuly Andrea Guerrero Martha Patricia Alba Liliana Patricia Lesmes José Oswaldo Escobar Manuel Elkin Patarroyo

Data Type

method:	in vivo assay

Study

name:	Redefining an epitope of a malaria vaccine candidate, with antibodies against the N-terminal MSA-2 antigen of Plasmodium harboring non-natural peptide bonds.
description:	In the epitope, the amide type peptide bond (CO-NH) was substituted with its reduced amide isotere bond psi-(CH2-NH) between residues Ile11 and Asn12. Passive transfer of the epitope-specific mAb into mice infected with P. berghei resulted in a delay in the emergence of significant percentages of parasitemia, enabled the animals to manage higher parasitemia levels and prolonged survival.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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