Factor VIII C1 domain spikes 2092-2093 and 2158-2159 comprise regions that modulate cofactor function and cellular uptake.

Title:

Factor VIII C1 domain spikes 2092-2093 and 2158-2159 comprise regions that modulate cofactor function and cellular uptake.

identifier:	2008905
description:	epitope description:K2111, F2112, I2177, R2178 antigen name:Coagulation factor VIII host organism:Homo sapiens antibody name:KM33
aggregation:	instance of dataset
availability:	available
primaryPublications:	24009077

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Esther Bloem Maartje van den Biggelaar Aleksandra Wroblewska Jan Voorberg Johan H Faber Marianne Kjalke Henning R Stennicke Koen Mertens Alexander B Meijer

method:	surface plasmon resonance (SPR)

name:	Factor VIII C1 domain spikes 2092-2093 and 2158-2159 comprise regions that modulate cofactor function and cellular uptake.
description:	The epitope- specific mAb bound to FVIII, but mutation at one of the epitope residues R2159N, eliminated the binding.

name:	iedb
homePage:	http://www.iedb.org

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