Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 2009286 |
| description: |
epitope description:R7, H210, G211, P213, T275, P276, F277, L278, A279, R282, D297, T298, N299, L300, H353, P354, E358, P361
antigen name:Beta-arrestin-1
host organism:Mus musculus
antibody name:Fab30
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
23604254 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1026901 |
| landingPage: |
http://www.iedb.org/assay/2009286 |
| type: |
Literature
|
| publicationVenue: |
Nature
|
| dates: |
2013
|
| study type: | b cell assays |
| subject species: | Rattus norvegicus |
| fullName: |
Arun K Shukla
Aashish Manglik
Andrew C Kruse
Kunhong Xiao
Rosana I Reis
Wei-Chou Tseng
Dean P Staus
Daniel Hilger
Serdar Uysal
Li-Yin Huang
Marcin Paduch
Prachi Tripathi-Shukla
Akiko Koide
Shohei Koide
William I Weis
Anthony A Kossiakoff
Brian K Kobilka
Robert J Lefkowitz
|
| method: |
chromatography
|
| name: |
Structure of active beta-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.
|
| description: |
The epitope residues are calculated from [PDB: 4JQI] as the antigen residues at 4 Å
atomic distance from the antibody.
Binding of the epitope-specific Fab30 to ß-arrestin-1 requires the presence of vasopressin V2 receptor phosphopeptide (V2Rpp), as demonstrated by isolation of the ternary complex by size exclusion chromatography.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
